California GOP Pins Its Hopes On Latinos

Hispanic voters are at the heart of a plan to rebuild and reinvigorate the Republican Party in California, the politician expected to take over the leadership of the state GOP has been telling insiders.

Former state Sen. Jim Brulte, the frontrunner to become the next chair of the California GOP has made the state?s Latino electorate the centerpiece of a makeover he says will turnaround the Republican Party?s fortunes.

?Jim Brulte says he has a six-year-plan to make the GOP the party of Hispanics in California,? says political consultant William Orozo. ?He says he?s going to make Latinos forget about Proposition 187 and Pete Wilson.

?And who knows? Politics sometimes has such a short attention span that in six years, 2019, he might just succeed.?

Prop 187 alienated Latinos and was the downfall of the California GOP

Proposition 187 is the anti-immigrant state measure that the GOP championed in the mid-1990s that many blame for alienating Latinos and for the downfall of the Republican Party in the state since that time.

Wilson was the Republican California governor who made Proposition 187 his personal crusade.

Approved by voters in 1994, the measure sought, among other things, to require police, health care professionals and teachers to verify and report the immigration status of all individuals, including children.

The courts eventually dismantled the measure and made it meaningless except as a symbol for Hispanics of GOP exclusion.

The decline of the state GOP became evident this past election in California when only 29 percent of the state?s voters were registered as Republicans, compared to 43 percent for Democrats.

On Monday, California Republican activists became the latest to meet in an attempt to figure out a game plan for making their party viable again.

It was at that meeting in San Diego that Brulte announced he would be a candidate for state GOP chairman, a position he is expected to win.

Jim Brulte may have a tough time with Tea Partiers

In pushing his plan to woo Latinos, though, Brulte will have to walk a fine line with the state?s die-hard conservatives and Tea Party people, say insiders.

?But Jim knows where the future of California politics is,? said one GOP insider. ?It?s the Latino vote, and he knows you have to go after it as you would a pretty girl because, as 2012 showed, the Latino vote is the darling of American politics right now.?

According to insiders, Brulte?s rebuilding is a six-year-plan because the state party has problems that go beyond having alienated Hispanics, resulting in not having any Republican holding a statewide elected office.

The state party is almost broke, with a half-million-dollar debt and down to only three full-time staffers, two of whom work from home. It also has almost no grassroots organization to speak of.

In Brulte, the GOP has a leader who typifies the about-face the party faces, say insiders.

His legislative record was that of a conservative, but he recognizes the new political landscape in California.

?His voting record is strongly conservative, but he also knows how to reach out to moderates and Democrats,? said Claremont McKenna College political scientist Jack Pitney.

Republican consultant Luis Alvarado, who is also president of the Republican National Hispanic Assembly of Greater Los Angeles, is among those Hispanics who are encouraged.

?We?re going back to the party of Shogun-type dynasties, where the Tea Party has their coalition, and the moderates have their coalition, and it?s going to be a battle to see who comes out on top,? he had said just weeks ago, in the aftermath of the election.

Now he says Brulte may be the ideal candidate for the political challenge at hand, adding:

?I have not heard a single person tell me that they would be opposed to him as a leader.?

This article originally appeared on VOXXI under the title "Latinos at Center of California GOP Rebuilding."

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Source: http://www.huffingtonpost.com/2013/01/16/california-republicans-latinos_n_2486931.html?utm_hp_ref=san-francisco&ir=San%20Francisco

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FSA mulls deadline for PPI claims on banks - sources

LONDON (Reuters) - Britain's financial regulator is considering putting a deadline on bank customers claiming compensation for being mis-sold insurance on their borrowings, sources familiar with the matter told Reuters.

The Financial Services Authority and UK banks are looking at ways to tackle the spiralling cost of compensating customers mis-sold payment protection insurance (PPI). Industry sources have said the total bill could be 25 billion pounds and take banks several years to clear as claims from customers and their agents such as dedicated claims management companies continue to pour in.

With each billion pounds paid out in PPI compensation cutting the amount banks can lend in real terms by 10 billion pounds, the industry has lobbied regulators to put a limit on how much longer customers can have to make claims. But one of the sources stressed that the talks were at an early stage.

"It is far from a done deal", the source said.

The Times newspaper said on Wednesday that the British Bankers Association had suggested a deadline of next summer in return for the banks agreeing to finance a widespread advertising campaign to ensure people are aware that they only have a limited time to make a claim.

The BBA confirmed on Wednesday that it was holding talks over PPI with the Financial Services Authority.

"The ongoing work focuses on three issues as a priority: addressing backlogs, making sure that customers can be confident that the offers they receive are right and highlighting that there is no need for them to engage a claims management company," the BBA said in a statement.

Banks have so far set aside more than 12 billion pounds to deal with the biggest mis-selling scandal in British history and are struggling to cope with a mounting backlog of complaints.

The policies were meant to protect borrowers who found themselves out of work because of sickness or redundancy but were found to have often been sold to customers who did not want or need them.

Last week, the Financial Ombudsman Services, which steps in when banks and their customers can't reach a settlement, said it was currently receiving 5,000 PPI-related complaints each week and was recruiting 1,000 new staff to process them.

The FSA said it was looking at ways to deal with the unprecedented level of claims.

"We have considered a number of options and continue to do so. PPI is an ongoing and high-profile issue and we are monitoring it closely," the regulator said.

Typically Lloyds Banking Group has an army of 6,000 workers processing claims and has put aside 5.3 billion pounds for compensation.

Banks are also co-operating more with claims management firms to process the claims, despite their public criticism of the companies, which have been urging borrowers to claim.

(Editing by Edwina Gibbs and Greg Mahlich)

Source: http://news.yahoo.com/fsa-mulls-deadline-ppi-claims-banks-sources-170716781--finance.html

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More Americans hunt, fish, and enjoy wildlife-associated recreation

Thirty-eight percent of Americans over 16 years of age hunted, fished, or participated in some kind of wildlife-related activity in 2011, according to the quinquennial national survey?issued by the U.S. Fish and Wildlife Service. In pursuit of their interests, these sportsmen and women spent $145 billion, or one dollar out of every hundred dollars of goods and services produced in the U.S.

Compared to the prior national survey, released in 2006, there was a 9 percent increase in hunting, with the biggest gains seen among migratory bird hunters. Fishing participation increased by 11 percent. Numbers of wildlife-watchers stayed steady.

The economic impact of outdoor sports and recreation is widespread, with money spent on equipment, travel and lodging, licenses and fees, membership dues and contributions, land leasing and ownership, and plantings for hunting. ?From local guides and restaurant workers to airlines and national manufacturers, numerous sectors of the economy benefit from Americans? enthusiasm to enjoy the outdoors and connect with the natural world.

Wildlife-associated recreation also results in significant financial support for conservation. A report?from the American Sportsfishing Organization points out that anglers? purchase of license fees and payment of excise taxes on tack and on motorboat fuel fund state fish and wildlife agency projects that improve water quality and support fisheries? and habitat conservation, contributing to the nation?s overall environmental health.

Source: http://beyondseasonsend.org/more-americans-hunt-fish-and-enjoy-wildlife-associated-recreation/

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Team finds gene that promotes drug resistance in cancer

Tuesday, January 15, 2013

Scientists from the University of Iowa and Brigham Young University (BYU) have identified a gene that may be a target for overcoming drug resistance in cancer. The finding could not only improve prognostic and diagnostic tools for evaluating cancer and monitoring patients' response to treatment but also could lead to new therapies directed at eradicating drug-resistant cancer cells.

Drug resistance is a common problem in many metastatic cancers. It leads to failure of chemotherapy treatments and is associated with poor patient outcomes, including rapid relapse and death.

The research team, including Fenghuang (Frank) Zhan, M.D., Ph.D., and Guido Tricot, M.D., Ph.D., from the UI, and David Bearss, Ph.D., from BYU, initially focused on identifying genes linked to the development of drug resistance in multiple myeloma, a bone marrow cancer that affects more than 20,000 Americans and causes almost 11,000 deaths annually.

Working with serial biopsied cells from 19 myeloma patients, the researchers analyzed genetic changes in the cells that occurred over the course of treatment with very intensive chemotherapy drugs. This approach identified a gene called NEK2 that is strongly associated with increased drug-resistance, faster cancer growth, and poorer survival for patients. The study was published Jan. 14 in the journal Cancer Cell.

Having established the relationship between high expression of the NEK2 gene and poor patient outcome in myeloma, the team then examined the relationship in other common cancers -- including breast, lung, and bladder cancer -- by analyzing gene expression profiles from 2,500 patients' cells with eight different cancers in Zhan's lab.

"In all cases, an increase in the NEK2 gene was associated with rapid death of the patient," says Tricot, who is director of Holden Comprehensive Cancer Center's Bone Marrow Transplant and Myeloma Program at UI Hospitals and Clinics. "So this finding was not unique to myeloma; this is basically seen in every single cancer we looked at."

Taking the findings back to the lab, the team then examined the effect on cancer cells of either enhancing or blocking the expression of the NEK2 gene.

"Our studies show that over-expression of NEK2 in cancer cells significantly enhances the activity of drug efflux proteins to pump chemotherapy drugs out of cells, resulting in drug resistance. Furthermore, silencing NEK2 in cancer cells potently decreased drug resistance, induced cell-cycle arrest, cell death, and inhibited cancer cell growth in vitro and in vivo," says Zhan, UI professor of internal medicine.

The research team is now developing compounds to inhibit NEK2 by collaborating with David Bearss, Ph.D., associate professor of physiology and developmental biology at BYU, in the hope that these compounds may overcome drug resistance in cancer cells.

"We were able to show that if we inhibit NEK2, then we can actually restore sensitivity to drugs that we use right now," Bearss says.

Although development and clinical testing of such drugs for use in patients is not imminent, Tricot notes that the findings may have clinical use within the next several years.

"NEK2 expression may be a diagnostic or prognostic marker for drug-resistant cancer," he says. "If NEK2 is high, that would suggest that the prognosis is poorer and the patient might benefit from more aggressive treatment. The other potential use is for monitoring the cancer's response to therapy. If NEK2 levels increase, that would suggest development of increased drug resistance and might indicate that a change of treatment would be helpful."

###

University of Iowa Health Care: http://www.uihealthcare.com/index.html

Thanks to University of Iowa Health Care for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 37 time(s).

Source: http://www.labspaces.net/126277/Team_finds_gene_that_promotes_drug_resistance_in_cancer_

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Enlightened, Season 2

As Amy?s manic effort to bring down Abaddon kicked in during Enlightened?s season premiere, so did Tyler?s reluctance to get drawn deeper into her game. Amy?s perennial sidekick?even after she rebuffed his fumbling advances?Tyler often seems even more hapless than our ostensible heroine. Amy tries to plunder more private emails of Abaddon?s higher-ups, but he balks, as only Tyler can: ?My aunt died and I just found out I got her timeshare, so I?m going to go to the Bahamas for two weeks a year!?

Tyler?s objections are at once pathetic and hilarious, as so much in Enlightened is. But when he finds out that he will lose his job whether or not he helps Amy, he allows himself to be drawn back into her grandiose, self-centered scheme, apparently because he detects a loneliness in Amy that mirrors his own. ?I don?t know anything else,? he tells her when she asks if he wants to stop feeling invisible. When Amy suggests that Tyler could become Time?s Person of the Year, he shares an eye roll with us, but his lingering stare also betrays a sense of longing that clearly gets his wheels turning.

If there is any real hero in Enlightened, Tyler has to be it. Amy?s enthusiasm for crushing Abaddon arises from a self-professed sense of ?obligation? that?s clearly her own need for self-renewal. She fits the self-righteous profile we often associate with whistleblowers, but Tyler is a complicated figure that may have more in common with whistleblowers in reality: He?s so used to being marginal that the alternative no longer seems appealing to him. He?s exactly the sort of broken-down drone Amy hopes to liberate, a fact that escapes them both. Not only does Tyler supply the means to bring down Abaddon (even with the password, Amy can?t figure out how to print the files), he also seems to embody the soul of the effort?and, crucially, provide an abiding reason they deserve to succeed.

Series co-creator Mike White cast himself in the role almost as an act of pity; he spares other actors the grim duty of playing a guy so broken that he accepts regular humiliation because his employee card helped get him a gym membership. White?a gaunt, pallid writer who occasionally acts?tends to write roles for himself that involve peripheral characters with a detached, sometimes ominous edge (if you haven?t caught his most famous role, in Chuck & Buck, do so immediately). That persona couldn?t be further from the man himself, if his unlikely bid on reality TV with his dad is to be believed, and yet he plays on his naturally eerie screen presence to revealing effect. The performance is so insistently unshowy that it?s easy to overlook the quiet, dutiful compass Tyler has become?both for Amy and for us.

Source: http://feeds.slate.com/click.phdo?i=be1ac9a4ea4e1f7511587e83dab3ec6c

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Amsterdam professors are sick en masse after party

AMSTERDAM (AP) ? Was it the fish?

An estimated 230 University of Amsterdam professors or their spouses got violently ill last week after the school's annual faculty party. Spokesman Joost van Tilburg said food poisoning was believed to be the cause.

He says the professors' distress "mostly involved stomach problems."

Some 400 people attended the party.

The results of an investigation by health authorities are due Thursday.

Source: http://news.yahoo.com/amsterdam-professors-sick-en-masse-party-153408891.html

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Armstrong comments on doping were not as expected: Oprah Winfrey

NEW YORK (Reuters) - Lance Armstrong "did not come clean in the way I expected" on whether he used performance-enhancing drugs in his cycling career, celebrated talk show host Oprah Winfrey said on Tuesday, a day after a lengthy interview with the disgraced athlete.

Armstrong, 41, has always vehemently denied using the drugs and had never tested positive to a doping test. But the evidence against him has been overwhelming and pressure has been building on him to admit that he cheated.

USA Today reported on Monday that Armstrong had confessed to the doping in the interview with Winfrey, which will air on Thursday and Friday on Winfrey's OWN Network, and other media say they have confirmed the report.

In an appearance on CBS' "This Morning" show on Tuesday, Winfrey stopped short of confirming a confession and said she would leave to others to decide if Armstrong had been contrite in the interview. She added that she found him to be thoughtful and serious.

When asked why Armstrong, who had his seven Tour de France titles stripped last year, had agreed to an interview that lasted more than two hours, Winfrey said: "I think he was just ready."

"I didn't get all the questions asked, but I think the most important questions and the answers that people around the world have been waiting to hear were answered," Winfrey told CBS.

A cancer survivor who went on to become the greatest cyclist the world has seen, Armstrong's fall from grace has been as swift and spectacular as his rise through the French Alps.

Long dogged by accusations he cheated his way to the top, an October report from the U.S. anti-doping body USADA ultimately triggered his rapid slide.

USADA exposed Armstrong as a liar and a cheat, describing him as the ringmaster of the "most sophisticated, professionalized and successful doping program that sport has ever seen," involving anabolic steroids, human growth hormone, blood transfusions and other doping.

(Reporting by Dan Burns; Editing by Paul Simao)

Source: http://news.yahoo.com/armstrong-admits-doping-during-winfrey-interview-report-012657188--spt.html

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Play.com closes direct retail business?.. | Hi-Def Ninja

Online retailer Play.com is to shut down its retail business to become a marketplace-only, from March.

The Jersey-based firm blamed the move on the ending of Low Value Consignment Relief, which allowed items less than ?15 to be sold to the UK VAT-free. All 147 staff in Jersey are to be made redundant as well as 67 in its Cambridge and Bristol offices. Play.com will now become more like a shopping centre, no longer selling directly to customers. The Low Value Consignment Relief (LVCR) loophole was closed by the UK government in April 2012.

In a statement Play.com said: ?Moving forward we are intending to focus exclusively on our successful marketplace, which is our main business area, and to phase out the direct-retail part of our business.?

A spokesperson confirmed the changes meant they were completely pulling out of Jersey, but about 200 staff would be left in the restructured company, which will be based in Cambridge.

Jersey?s Economic Development Minister, Senator Alan Maclean, said now in total about 600 people had lost their jobs in the island because of the end of LVCR. Senator Maclean said: ?I?m saddened, this is a Jersey business, set up in the island that did extraordinarily well, that became a global brand. We will work with other businesses and entrepreneurs to help them develop the next Play.com.? He said the government would do all it could to support those out of work.

David Warr, president of Jersey?s Chamber of Commerce, said it was another hammer blow to the island?s economy. He said: ?That?s a significant increase in the number of people unemployed? and obviously that should be a concern to everyone. I think we are going to have to work very hard to find these people new places to work.?

Garry Todd, a tax analyst, said LVCR ended almost a year ago and most businesses that would close have, indicating Jersey is through the worst of it.

In September 2011, Play.com was taken over by Japanese e-commerce operator Rakuten. It paid ?25m ($39.3m, 28.6m euros) for the company, which at the time had 14m registered users and was one of the largest online retailers in the UK.

Source: http://www.hidefninja.com/2013/01/13/play-com-closes-direct-retail-business/

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